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MORE ABOUT THIS BOOK
Main description:
This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of Fc RI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including Fc RIIB and Fc RI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
Contents:
Part I : Old and new FcRs
Hiromi Kubagawa, Yoshiki Kubagawa, Dewitt Jones, Tahseen H. Nasti, Mark Walter, and Kazuhito Honjo
The Old but New IgM Fc Receptor (Fc R)
F.J. Li, W.J. Won, E.J. Becker Jr., J.L. Easlick, E. Tabengwa, R. Li, M. Shakhmatov, P.D. Burrows, and R.S. Davis
Emerging Roles for FCRL Family Members in Lymphocyte Biology and Disease
Leo C. James
Intracellular antibody immunity and the cytosolic Fc receptor TRIM21
Part II: FcR signaling
Anna Niarakis, Yacine Bounab, Luca Grieco, Roman Roncagalli, Jerome Garin, Bernard Malissen, Marc Daeron, Denis Thieffry
Computational modeling of the main signaling pathways involved in mast cell activation
Tarik Attout, Andres Floto and Pierre Launay
Calcium channels in FcR signaling
Marcel Kuhny, Carolin N. Zorn, and Michael Huber
Regulation of Fc RI signaling by lipid phosphatases
Part III: FcR biology
Marc Daeron
Fc Receptors as Adaptive Immunoreceptors
Jerrard M Hayes, Eoin FJ Cosgrave, Weston B Struwe, Mark Wormald, Gavin P. Davey, Roy Jefferis, Pauline M Rudd
Glycosylation and Fc Receptors
Birgitta Heyman
Antibodies as natural adjuvants
Sanae Ben Mkaddem, Ivy Christou, Elisabetta Rossato, Laureline Berthelot, Agnes Lehuen and Renato C. Monteiro
IgA, IgA receptors and their anti-inflammatory properties
Stylianos Bournazos, David J. DiLillo and Jeffrey V. Ravetch
Humanized mice to study Fc R function
Dilip K. Challa, Ramraj Velmurugan, Raimund J. Ober and E. Sally Ward
FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions.
Part IV: FcRs and disease
Xinrui Li, Andrew W Gibson and Robert P Kimberly
Human FcR polymorphism and disease.
Hanane el Bannoudi, Andreea Ioan-Facsinay and Rene E. M. Toes
Bridging auto-antibodies and arthritis; the role of Fc Receptors
P. Mark Hogarth, Jessica C. Anania, Bruce D. Wines
The Fc R of humans and non-human primates and their interaction with IgG: Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies
Part V: FcRs and therapeutic antibodies
Ann L White, Stephen A Beers and Mark S. Cragg
FcgRIIB as a key determinant of agonistic antibody efficacy
Jantine E. Bakema and Marjolein van Egmond
Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work
Sybille Boehm, Daniela Kao and Falk Nimmerjahn
Sweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin G
PRODUCT DETAILS
Publisher: Springer (Springer International Publishing AG)
Publication date: August, 2014
Pages: 300
Weight: 7804g
Availability: Available
Subcategories: General Issues, Immunology
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