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MORE ABOUT THIS BOOK
Main description:
Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.
Contents:
Neurosteroids: From Definition and Biochemistry to Physiopathologic Function, Paul Robel, Michael Schumacher, and Etienne-Emile Baulieu. Molecular Biology and Developmental Regulation of the Enzymes Involved in the Biosynthesis and Metabolism of Neurosteroids, Synthia H. Mellon and Nathalie A. Compagnone. Cytochrome P450 in the Central Nervous System, Margaret Warner and Jan-Ake Gustafsson. Steroidogenic Factor 1 Plays Key Roles in Adrenal and Gonadal Development and in Endocrine Function, Kathleen M. Caron, Yayoi Ikeda, Xunrong Luo, and Keith L. Parker. Peripheral-Type Benzodiazepine Receptor: Role in the Regulation of Steroid and Neurosteroid Biosynthesis, Caterina Cascio, Patrizia Guarneri, Hua Li, Rachel C. Brown, Hakima Amri, Noureddine Boujrad, Maria Kotoula, Branislav Vidic, Katy Drieu, and Vassilios Papadopoulos. Aspects of Hormonal Steroid Metabolism in the Nervous System, Angelo Poletti, Fabio Celotti, Roberto Maggi, Roberto C. Melcangi, Luciano Martini, and Paola Negri-Cesi. The Selective Interaction of Neurosteroids with the GABAA Receptor, Jeremy J. Lambert, Delia Belelli, Susan E. Shepherd, Marco Pistis, and John Peters. Potentiation of GABAergic Neurotransmission by Steroids, Robert H. Purdy and Steven M. Paul. Neurosteroid Antagonists of the GABAA Receptors, Maria Dorota Majewska. Modulation of Ionotropic Glutamate Receptors by Neuroactive Steroids, Terrell T. Gibbs, Nader Yaghoubi, Charles E. Weaver, Jr., Mijeong Park-Chung, Shelley J. Russek, and David H. Farb. Steroidal Modulation of Sigma Receptor Function, Stephane Bastianetto, Francois Monnet, Jean-Louis Junien, and Remi Quirion. Steroid Modulation of the Nicotinic Acetylcholine Receptor, Bruno Buisson and Daniel Bertrand. Neuroactive Steroid Modulation of Neuronal Voltage-Gated Calcium Channels, Jarlath M. H. ffrench-Mullen. Gonadal Hormone Regulation of Synaptic Plasticity in the Brain: What Is the Mechanism? Bruce S. McEwen. Steroid Effects on Brain Plasticity: Role of Glial Cells andTrophic Factors, Luis Miguel Garcia-Segura, Julie Ann Chowen, Frederick Naftolin, and Ignacio Torres-Aleman. Steroid Receptors in Brain Cell Membranes, Victor D. Ramirez and Jianbiao Zheng. Novel Mechanisms of Estrogen Action in the Developing Brain: Role of Steroid/Neurotrophin Interactions, C. Dominique Toran-Allerand. Neurosteroids: Behavioral Studies, Willy Mayo, Monique Valee, Muriel Darnaudery, and Michel Le Moal. Remarkable Memory-Enhancing Effects of Pregnenolone Sulfate with Pheromone-like Sensitivity, Eugene Roberts. The Neuropsychopharmacological Potential of Neurosteroids, Rainer Rupprecht, Elisabeth Friess, and Florian Holsboer.
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 396
Weight: 830g
Availability: Available
Subcategories: Endocrinology, Neurology, Pharmacology
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