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Main description:
Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
Contents:
Basic Studies
I. Molecular Mechanisms of Estrogen Receptor Function
Structure and Function of the Estrogen Receptor
Stefan Nilsson and Jan-Ake Gustafsson
Ligand-Induced Conformational Changes in Estrogen Receptors-a and -b
Elizabeth A. Allegretto
Expression and Function of Estrogen Receptors-a and -b
Jonathan Lindzey
SERM Modulation of Gene Expression: Role of Coactivators and Corepressors
Paul Webb
Crosstalk Between Estrogen Receptors and Growth Factor Signaling
Douglas Yee and Carol A. Lange
II. Tissue-Specific Effects of Estrogens and SERMs
Direct Estrogen Effects on the Cardiovascular System
Munish K. Goyal and Suzanne Oparil
Estrogens and the Brain: Implications for the Treatment of Postmenopausal Women
Bruce S. McEwen, Phyllis M. Wise, and Stanley Birge
III. Preclinical Studies
Insights into the Molecular Mechanism of SERMs Through New Laboratory Models
Csaba Gajdos, James Zapf, and V. Craig Jordan
Third- and Fourth-Generation SERMs, Fernand Labrie
Claude Labrie, Alain Belanger, and Jacques Simard
Clinical Studies
IV. Organ Specific Effects of Estrogens and SERMs
SERMs' Effect on the Neuroendocrine System and the Reproductive Organs
Nanette F. Santoro and Peter Kovacs
Epidemiology of Cardiovascular Disease in Women: Role of Estrogens
Jacques E. Rossouw
SERMs Effects on Cardiovascular Risk Factors and Disease
Richard R. Love
Estrogen and the Skeleton
Michael Kleerekoper and Ashish Verma
Effects of SERMs on Bone in Clinical Studies
Aurelie Fontana and Pierre D. Delmas
Estrogens and SERMs: Clinical Aspects of Cognition with Aging and Neurodegenerative Disorders
Alan J. Lerner
V. SERMs and Endocrine Dependent Tumors
SERMs and Breast CancerPrevention
Jenny Chang and C. Kent Osborne
SERMs in Postmenopausal Women's Health
Jan L. Shifren and Leo Plouffe, Jr.
VI. Roles of Estrogens and SERMs in Postmenopausal Hormone Replacement Therapy
Menopause Therapy: An Individualized Approach
Nananda F. Col, Michele G. Cyr, and Anne W. Moulton
Alternatives to Estrogen for Treatment of Menopause
Richard J. Santen and JoAnn V. Pinkerton
Phytoestrogens in the Context of SERMs
Susan R. Davis
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2012
Pages: 384
Weight: 728g
Availability: Not available (reason unspecified)
Subcategories: Endocrinology
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