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MORE ABOUT THIS BOOK
Main description:
This volume gives an overview on the progress in immune synapse research, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation, and the recruitment of regulatory T cells; the role of monoclonal antibodies in tolerance induction; and mechanisms maintaining dominant tolerance.
Contents:
The immune synapse and T cell activation: regulation by chemokines.- The induction of regulatory T cells by targeting the immune synapse.- Infiltrating the immunological synapse: prospects for the use of altered petide ligands for the treatment of immune pathology.- Targeting CD4 for the induction of dominant tolerance.- Anti-CD3: from T cell depletion to tolerance induction.- Immune modulation by CD40L blockade.- CTLA-4-Ig and indoleamine 2,3-dioxygenase (IDO) in dominant tolerance.- Adhesion molecules as therapeutic targets.- E3 ubiquitin ligases and immune tolerance: targeting the immune synapse from within?.- FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells.- TGF-ss: from its effect in T cell activation to a role in dominant tolerance.- From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.
PRODUCT DETAILS
Publisher: Springer (Birkhauser Verlag AG)
Publication date: October, 2007
Pages: 203
Weight: 556g
Availability: Available
Subcategories: General Issues, Immunology, Infectious Diseases, Pharmacology
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