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MORE ABOUT THIS BOOK
Main description:
Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. To improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. Current Advances in Osteosarcoma summarizes all of these new discoveries in one singular text, which will help move the field forward.
Feature:
The volume comprehensively covers the biology of osteosarcoma, including seminal discoveries of molecular pathways and genetic alterations that lead to metastasis
The topics provide a starting block for unified discussions for osteosarcoma researchers in order to move the field forward
The volume editor is an internationally recognized leader in the field of sarcomas, particularly osteosarcoma
Back cover:
Current Advances in Osteosarcoma summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in this field over the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and is the most common histological form of bone cancer. Osteosarcoma accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat.
In order to improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. This volume will provide a comprehensive review of these new discoveries in one singular text, which will help move the field forward.
Contents:
Historical Perspective on the Introduction and Use of Chemotherapy for the Treatment of Osteosarcoma
Norman Jaffe
Wnt Signaling in Osteosarcoma
Carol H Lin, Tao Ji, Cheng-Fong Chen, Bang H Hoang
Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspects
Ashley N. Rettew, Patrick J Getty, and Edward M. Greenberg
Understanding the Role of Notch in Osteosarcoma
Madonna M McManus, Kurt R Weiss, and Dennis PM Hughes
Developmental Pathways Highjacked by Osteosarcoma
Yi Zhang, Jared R Mortus, and Dennis PM Hughes
MicroRNAs in Osteosarcomagenesis
Lisa A Kafchinski and Kevin B Jones
RECQ DNA Helicases and Osteosarcoma
Linchao Lu, Weidong Jin, Hao Liu, and Lisa L Wang
Autophagy in Osteosarcoma
Janice Santiago O’Farrill and Nancy Gordon
HER-2 Involvement in Osteosarcoma
Jonathan Gill, David Geller, and Richard Gorlick
Role of Ezrin in Osteosarcoma Metastasis
Ling Ren and Chand Khanna
Participation of the Fas/FasL Signaling Pathway and the Lung Microenvironment in the Development of Osteosarcoma Lung Metastases
Gangxiong Huang, Kazumasa Nishimoto, Yuanzheng Yang, and Eugenie S Kleinerman
Zebrafish as a Model for Human Osteosarcoma
AB Mohseny and Pancras CW Hogendoorn
Using Canine Osteosarcoma as a Model to Assess Efficacy of Novel Therapies: Can Old Dogs Teach Us New Tricks?
Carlos O Rodriguez
Oncolytic Viruses for Potential Osteosarcoma Therapy
Pooja Hingorani, Valerie Sampson, Christina Lettieri, E. Anders Kolb
IL-11Rα: A Novel Target for the Treatment of Osteosarcoma
Valerae Lewis
Bone-seeking Radiopharmaceuticals as Targeted Agents of Osteosarcoma: Samarium-153-EDTMP and Radium-223
Peter M Anderson, Vivek Subbiah, and Eric Rohren
Muramyl Tripeptide-phophatidyl Ethanolamine Encapsulated in Lipomes (L-MTP-PE) in the Treatment of Osteosarcoma
Paul A Meyers
Genetically Modified T-cell Therapy for Osteosarcoma
Christopher DeRenzo and Stephen Gottschalk
Natural Killer Cells for Osteosarcoma
Nidale Tarek, and Dean A Lee.
PRODUCT DETAILS
Publisher: Springer (Springer International Publishing)
Publication date: July, 2014
Pages: 300
Weight: 767g
Availability: Not available (reason unspecified)
Subcategories: Microbiology, Oncology, Paediatrics and Neonatal
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CUSTOMER REVIEWS
From the book reviews:
“The work is both relevant and timely as no other book fills this particular niche in the field of osteosarcoma. … book is written for students, clinicians, and scientists seeking a review of the biology of osteosarcoma. … Graduate students, medical residents and fellows, and postdoctoral researchers beginning osteosarcoma research projects will find it a very useful introduction to the broad scope of osteosarcoma science. … a worthy addition to the library of all who are interested in osteosarcoma science.” (George Calvert, Doody’s Book Reviews, February, 2015)