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Main description:
These two volumes record the scientific and clinical work presented at the VIIth International and 3rd European joint symposium on purine and pyrimidine metabolism in man held at the Bournemouth International Conference Centre, Bournemouth, UK, from 30th June to 5th July 1991. The series of international meetings at three yearly intervals have previously been held initially in 1973 in Israel, then Austria, Spain, the Netherlands, USA and Japan. The European Society for the Study of Purine and pyrimidine Metabolism in Man (ESSPPM) which has its own executive and some finance first met in switzerland in 1987, then in Germany in 1989. The steady evolution of the science in this series of meetings is intellectually satisfying; the subsequent clinical progress is emotionally and economically reassuring. As befits the position of purines and pyrimidines at the centre of biochemistry, there has been steady scientific development into molecular genetics and now onto developmental controls and biochemical pharmacology. The complexities of the immune system are being unravelled but an understanding of the human brain largely eludes us. Laboratory based scientists now predominate over those who work as clinical specialists in VIi rheumatology, immunology, oncology and paediatrics. However, there continue to be major clinical objectives since large sections are concerned with major causes of death like ATP depletion, cancer and now AIDS; the laboratory work is providing clinical solutions.
Contents:
B Structural Biochemistry, Pathogenesis and Metabolism.- D. Measurement of Purine and Pyrimidines in Tissues and Biological Fluids.- Capillary Electrophoresis for the Analysis of Cellular Nucleotides.- An Improved Screening Method for Inherited Disorders of Purine and Pyrimidine Metabolism by HPLC.- A Single HPLC System for the Evaluation of Purine and Pyrimidine Metabolites in Body Fluids.- Simple Method for the Quantitative Analysis of Dihydropyrimidine and N-Carbamyl-?-Aminoacids in Urine.- Diagnostic Potential of HPLC: Experimental and Clinical Trials.- Reference Values of Orotic Acid, Uracil and Pseudouridine in Urine.- Automated Quantitative Analysis for Orotidine and Uridine/Thymine in Urine by High-Performance Liquid Chromatography with Column Switching.- HPLC Assay of Uridine Monophosphate Synthase (UMPS) in Chorionic Villus Samples (CVS) and Erythrocytes (RBC).- A RP-HPLC Method for the Measurement of Guanine, Other Purine Bases and Nucleosides.- Some Aspects of Purine Nucleotide Metabolism in Human Lymphocytes. Before and after Infection with HIV-I Virus: Nucleotide Content.- Prenatal Diagnosis of Lesch-Nyhan Syndrome by Purine Analysis of Amniotic Fluid and Cordocentesis.- E. Structural Biochemistry.- Gene Therapy in Man and Mice: Adenosine Deaminase Deficiency, Ornithine Transcarbamylase Deficiency and Duchenne Muscular Dystrophy.- Regulation of the Human Adenosine Deaminase Gene by First Intron Sequences in a T-cell Enhancer.- Expression of the APRT Gene in an Adenovirus Vector System as a Model for Studying Gene Therapy.- Transcriptional Regulation of Ribonucleotide Reductase.- Mutational Basis of Adenine Phosphoribosyl-Transferase Deficiency.- Analysis of the Promoter Region of the CHO APRT Gene.- A Splice Mutation at the Adenine Phosphoribosyltransferase Locus Detected in a German Family.- Germline and Somatic Mutations Leading to Adenosine Phosphoribosyltransferase (APRT) Deficiency.- Long - Term Evolution of Type 1 Adenine Phosphoribosyltransferase (APRT) Deficiency.- A Strategy for the Creation of Mutations in Human HPRT-cDNA and the Expression of Recombinant Proteins in E. coli.- Molecular Analysis of Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in Japanese Patients.- Expression of Normal and Variant Human Hypoxanthine-Guanine Phosphoribosyltransferase in E. coli.- HPRT Gene Mutations in a Female Lesch-Nyhan Patient.- Molecular Analysis of Human HPRT Gene Deletions and Duplications.- Rat Hypoxanthine Phosphorbosyltranferase cDNA Cloning and Sequence Analysis.- Identification of Two Independent Japanese Mutant HPRT Genes Using the PCR Technique.- Identification of Distinct PRS1 Mutations in Two Patients with X-Linked Phosphoribosylpyrophosphate Synthetase Superactivity.- Human Phosphoribosylpyrophosphatase (PRS)2: an Independently Active, X Chromosome-Linked PRS Isoform.- Rescue of Lethal Purine Nucleoside Phosphorylase Mutation in the Mouse via a Second Locus Interaction.- Genetic Models of Purine Nucleoside Phosphorylase Deficiency in the Mouse..- A Genetic Defect in Muscle Phosphofructokinase Deficiency, a Typical Clinical Entity Presenting Myogenic Hyperuricemia.- 5?-Nucleotidase: an Overview of the Last Three Years.- Cytosolic Purine 5?-Nucleotidase from Chicken Heart: an Isozyme of the Liver Enzyme as Evidenced by Antibodies.- Amplification of T-cell Activity Induced by CD73 (Ecto 5?-Nucleotidase) Engagement.- Studies on the Structure and Biosynthesis of the Phosphatidyl-Inositol-Glycan Anchor and the Carbohydrate Side Chains of Human Placental Ecto 5?-Nucleotidase.- Diphosphonucleosides Are Indispensable Cofactors of AMP-Specific Cytoplasmic 5?-Nucleotidase Catalysed Reaction.- Adenosine Metabolising Enzymes in Bull and Human Spermatozoa.- Cytosolic 5?-Nucleotidase/Phosphotransferase of Human Colon Carcinoma.- Purine Nucleoside Phosphorylase: Allosteric Regulation of a Dissociating Enzyme..- Purine Nucleoside Phosphorylase of Bovine Liver Mitochondria.- Uridine and Purine Nucleoside Phosphorylase Activity in Human and Rat Heart.- A Comparative Study of the Small Forms of Adenosine Deaminase from Various Organisms.- Adenosine Deaminase in the Diagnosis of Pleural Effusions.- Molecular Forms of Human Kidney AMP Deaminase.- Molecular Analysis of Acquired Myoadenylate Deaminase Deficiency in Polymyositis (Idiopathic Inflammatory Myopathy).- Molecular Genetic Analysis of Chromosome 9p in Methylthioadenosine Phosphorylase Deficient Glioma Cell Lines.- S-Adenosylhomocysteine Hydrolase Activity in Erythrocytes from HIV-Infected Patients.- Purification and Characterization of Recombinant Rat Phosphoribosylpyrophosphate Synthetase Subunit I and Subunit II.- Rapid Purification of a Bifunctional Protein Complex Possessing Phosphoribosylaminoimidazole Carboxylase (EC 4.1.1.21) and Phosphoribosylaminoimidazolesluccinocarboxamide Synthetase (EC 6.3.2.6) Activities.- Highest ADA Expressing Mouse Tissues also Exhibit Cell-Type Specific Coordinate Up-Regulation of Purine Degradative Enzymes.- Cytidine Deaminase: A Rapid Method of Purification and some Properties of the Enzyme from Human Placenta.- Expression and Substrate Specificities of Human Thymidine Kinase 1, Thymidine Kinase 2 and Deoxycytidine Kinase.- Pyrimidine 5?-Nucleotidase (S) of Human Erythrocytes: Enzymatic and Molecular Characterization.- F. Pathogenesis.- GTP Activates Two Enzymes of Pyrimidine Salvage from the Human Intestinal Parasite Giardia intestinalis.- Possible Metabolic Basis for the GTP Depletion in Red Cells of Patients with PRPP Synthetase Superactivity.- Guanine Metabolism in Primary Rat Neuronal Cells.- Urinary Pterins in Lesch-Nyhan Syndrome.- Basis for the Chondro-Osseous Dysplasia Associated with Adenosine Deaminase Deficiency: Selective Toxicity to Immature Chondrocytes.- Analysis of Forebrain Dopaminergic Pathways in HPRT-Deficient Mice.- Absence of dGTP Accumulation and Compensatory Loss of Deoxyguanosine Kinase in Purine Nucleoside Phosphorylase Deficient Mice.- Adenylosuccinase Activity and Succinylpurine Production in Fibroblasts of Adenylosuccinase-Deficient Children.- G. Metabolic Biochemistry.- Purine Nucleotide Cycle, Molecular Defects and Therapy.- IMP Dehydrogenase and GTP as Targets in Human Leukemia Treatment.- Guanine Ribonucleotide Depletion Inhibits T Cell Activation.- Raised IMP-Dehydrogenase Activity in the Erythrocytes of a Case of Purine Nucleoside Phosphorylase (PNP) Deficiency.- Guanine Ribonucleotide Metabolism and the Regulation of Myelopoiesis.- Pyrimidine Pathways: News Concerning the Mechanism of Orotidine-5?-Monophosphate Decarboxylase.- Dihydropyrimidine Dehydrogenase Deficiency in a Hutterite Newborn.- Superactive UMP Hydrolase: Cause or Consequence of Haemolytic Anaemi?.- NAD Synthesis in Human Erythrocytes: Study of Adenyl Transferase Activities in Patients Bearing Purine Enzyme Disorders.- Pyridine Nucleotide Metabolism: Purine and Pyrimidine Interconnections.- NAD Synthesis in ADA Deficient Erythrocytes of the Opossum Didelphis virginiana.- Pyridine Nucleotide Metabolism: Purification and Properties of NMN Adenylyltransferase from Human Placenta.- NAD Synthesis in Human Erythrocytes: Determination of the Activities of some Enzymes.- Applications of PRPP Metabolism in human Erythrocytes.- A Syndrome of Megaloblastic Anemia, Immunodeficiency and Excessive Nucleotide Degradation.- Adenine Nucleotide Catabolism in the Erythrocytes of Uraemic Patients.- Nucleotide Catabolism in Red Blood Cells of Rabbit.- The Effect of Aspirin on Blood Cell Nucleotides in Vivo.- AICAriboside Inhibits Gluconeogenesis in Isolated Rat Hepatocytes.- Z-Nucleotides Formation in Human and Rat Cells.- Purine Metabolism in Regenerating Liver-Bearing Rats.- Purine Nucleotide Synthesis in Rat Liver after Castration.- Incorporation of Purine Ribonucleotides into Nucleic Acids of Rat Liver after Castration.- The Effect of Pyrolline-5-Carboxylate on R5P and PRPP Generation in Mouse Liver in Vivo.- Effects of Oral Ribose on Muscle Metabolism during Bicycle Ergometer in Patients with AMP Deaminase Deficiency.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: June, 2012
Pages: 416
Weight: 787g
Availability: Available
Subcategories: Biochemistry
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