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Main description:
These volumes contain the papers which were presented at the Third International Symposium on Purine Metabolism in Man held in Madrid (Spain) in June, 1979. The previous meetings in the series were held in Tel Aviv (Israel) and in Baden (Austria) in 1973 and 1976, respectively. The proceedings were also published by Plenum. Knowledge of the pathophysiology of the purines has developed greatly since the 1950's when it was mainly related to clinical gout, and it is now relevant to many fields of Medicine and Biology. These volumes include papers reporting new work on clinical gout and urolithiasis as well as on some of the subjects which have featured prominently in the previous volumes, including: regulatory aspects of the intermediary metabolism of purines and related com pounds, enzymology, methodology, and the results of mutations which affect purine metabolism. However, there have been many new develop ments during the last three years and the scope of the communications reflects not only increasing depth of knowledge, but also a widening of the field. This publication has clinical and fundamental impli cations for internal medicine, pediatrics, urology, biochemistry, immunology, genetics, and oncology.
Contents:
of Part B.- I. Purine Metabolism Pathways and Regulation.- A. De Novo Synthesis: Precursors and Regulation.- De Novo Purine Synthesis in Cultured Human Fibroblasts.- Comparative Metabolism of a New Antileishmanial Agent, Allopurinol Riboside, in the Parasite and the Host Cell.- Purine Metabolism in Rat Skeletal Muscle.- Alterations in Purine Metabolism in Cultured Fibroblasts with HGPRT Deficiency and with PRPPP Synthetase Superactivity.- Purine Metabolism in Cultured Endothelial Cells.- Determinants of 5-Phosphoribosyl-1-Pyrophosphate (PRPP) Synthesis in Human Fibroblasts.- Xanthine Oxidoreductase Inhibition by NADH as a Regulatory Factor of Purine Metabolism.- B. Nucleotide Metabolism.- Human Placental Adenosine Kinase: Purification and Characterization.- Long-Term Effects of Ribose on Adenine Nucleotide Metabolism in Isoproterenol-Stimulated Hearts.- C. Salvage Pathways.- Purine Salvage Enzymes in Man and Leishmania donovani.- Regulation of Purine Salvage Enzymes in E. coli.- D. Catabolism.- Purine Transport and the Cell Cycle.- Hypoxanthine Transport in Human Erythrocytes.- Uptake of Adenosine in Human Erythrocytes.- Effect of Actinomycin D on in vivo Purine Biosynthesis in Hamster Cells.- Purine Catabolism in Isolated Hepatocytes: Influence of Coformycin.- II. Enzymology and Purine Metabolism.- A. Phosphoribosyltransferases.- Inactivation of Hyposanthine Guanine Phosphoribosyltransferase by Guanosine Dialdehyde: An Active Site Directed Inhibitor.- Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Nucleotide Interconversion.- Purification and Characterization of Mammalian Adenine Phosphoribosyltransferase.- The Effect of Phosphoribosylpyrophosphate on Stability and Configuration of Hypoxanthineguaninephosphoribosyltransferase and Adeninephosphoribosyltransferase from Human Erythrocytes.- Chemical Modification of Hypoxanthine-phosphoribosyltransferase and Its Protection by Substrates and Products.- B. Nucleoside Phosphoribosylating Enzymes.- Structural Studies of Human Adenine Phosphoribosyltransferase Purified by Affinity Chromatography.- Phosphoribosylpyrophosphate (PRPP) Synthetase Mutant in Salmonella typhimurium.- C. Nucleoside Cleaving Enzymes.- Methylmercaptopurine Ribonucleoside Toxicity in Human Fibroblasts: Inhibition of Phosphoribosylpyrophosphate Synthetase as well as Amidophosphoribosyltransferase.- Adenosine Kinase: Regulation by Substrates, Magnesium, and pH.- Adenosine and Deoxyadenosine Kinase from Rat Liver.- D. Deaminating Enzymes.- Radioimmunochemical Analysis of Human Erythrocyte Adenosine Deaminase.- Adenosine Deaminase Conversion Proteins: A Potential Role.- Regulatory Properties of AMP Deaminase Isozymes.- Human Adenosine Deaminase: Stoichiometry of the Large Form Complex.- Guanase from Human Liver - Purification and Characterization.- E. Oxidating Enzymes.- Nicotinamide and Liver Xanthine Oxidase.- Xanthine Oxidase Activity in Human Intestines. Histochemical and Radiochemical Study.- III. Pyrimidine Metabolism.- Purine and Pyrimidine Metabolism in Hereditary Oroticaciduria During a 15-Year Follow-Up Study.- Effect of Allopurinol on Pyrimidine Metabolism in Human White Blood Cells: Role of the Salvage Pathway.- Kinetics and Compartmentation of Erythrocyte Pyrimidine Metabolism.- Simultaneous Determination of Rates of Purine and Pyrimidine Synthesis in Cultured Human Lymphoblasts and Fibroblasts.- Activities of Enzymes of Purine and Pyrimidine Metabolism in Nine Mycoplasma Species.- IV. Lymphocyte Purine Metabolism Research.- Increases in Purine Excretion and Rate of Synthesis by Drugs Inhibiting IMP Dehydrogenase or Adenylosuccinate Synthetase Activities.- Possible Role for 5?-Nucleotidase in Deoxyadenosine Selective Toxicity to Cultured Human Lymphoblasts.- Cyclic Nucleotide Levels and Mechanism of Inhibition of Leucocyte Function by Adenosine Deaminase Inhibition.- Purine Ribonucleoside and Deoxyribonucleoside Metabolism in Thymocytes.- Molecular Mechanism(s) of Deoxyribonucleoside in T-Lymphoblasts.- Inhibition of Immune Cell Function by Adenosine: Biochemical Studies.- Interactions Between Energy Metabolism and Adenine Nucleotide Metabolism in Human Lymphoblasts.- Enzymes of Purine Interconversions in Subfractions of Lymphocytes.- Measurement of the Rates of Synthesis and Degradation of Hypoxanthine-guanine phosphoribosyltransferase in Human Lymphoblasts.- Human 5?-Nucleotidase. Properties and Characterization of the Enzyme from Placenta. Lymphocytes and Lymphoblastoid Cells in Culture.- Metabolism and Toxicity of 9-Beta-D-Arabinofuranosyladenine in Human Malignant T Cells and B Cells in Tissue Culture.- V. Immune System and Purine Metabolism.- Suppression of Cellular Immunity Due to Inhibition of Purine Nucleoside Phosphorylase by Allopurinol-Riboside.- Lymphocyte 5?-Nucleotidase Deficiency: Clinical and Metabolic Characteristics of the Associated Hypogammaglobulinemia.- Immunological Studies on Lesch-Nyhan Patients.- Activity of Ecto-5?-Nucleotidase in Lymphoblastoid Cell Lines Derived from Carriers of Congenital X-Linked Agammaglobulinemia.- VI. Cancer Research.- Adenosine Deaminase and Purine Nucleoside Phosphorylase in Acute and Chronic Lymphatic Leukemia.- Purine Salvage Enzymes in Lymphocytes and Granulocytes from Patients with Small-Cell Carcinoma of the Lung.- Treatment of Acute Lymphoblastic Leukemia with the Adenosine Deaminase Inhibitor 2?-Deoxycoformycin.- Increase of Phosphoribosylpyrophosphate Levels in Cultured L1210 Leukemia Cells Exposed to Methotrexate.- Purine Salvage Pathway in Leukemic Cells.- Biochemical Consequences of Treatment with the Adenosine Deaminase Inhibitor 2?-Deoxycoformycin.- In vitro and in vivo Effect of Deoxycoformycin in Human T Cell Leukemia.- Uniqueness of Deoxyribonucleotide Metabolism in Human Malignant T Cell Lines.- VII. Methodology.- High Performance Liquid Chromatography of Plasma Pyrimidines and Purines and Its Application in Cancer Chemotherapy.- Urate-Binding Proteins in Plasma Studied by Affinity Chromatography.- Chromatographic Determination of PRPP-Synthetase Activity in Human Blood Cells.- Purification of Myocardial Adenosine Kinase Using Affinity and Ion-Exchange Chromatography.- Micromethods for the Measurement of Purine Enzymes in Lymphocytes.- A Rapid Screening Method for Inborn Errors of Purine and Pyrimidine Metabolism Using Isotachophoresis.- Analysis of Serum Purines and Pyrimidines by Isotachophoresis.- Determination of Uric Acid in Serum: Comparison of a Standard Enzymatic Method and Isotachophoresis.- Addition Products of Uric Acid and Formaldehyde.- Automated Retrieval of Purine Literature.- Author Index.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: November, 2012
Pages: 459
Weight: 913g
Availability: Available
Subcategories: Biochemistry
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