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Main description:
This book summarizes the keynote and plenary speeches and posters of the Xth International Nidovirus Symposium: Toward Control of SARS and Other Nidovirus Diseases” that was held in Colorado Springs, Colorado, June 25–30, 2005. The nine previous meetings of scientists investigating the molecular biology and pathogenesis of coronaviruses, toroviruses, arteriviruses, and okaviruses were generally held every 3 years since the first meeting was convened in Wurzburg, Germany, in October, 1980. The Xth International Symposium was held just 2 years after the IXth International Symposium (Nido2003) in The Netherlands, because of the tremendously increased research on nidoviruses that resulted from the discovery that the global epidemic of severe acute res- ratory syndrome (SARS) in 2002–2003 was caused by a newly discovered coronavirus called SARS-CoV. A record 225 scientists from 14 countries attended the Xth International Nidovirus Symposium, and important advances in every aspect of nidovirus molecular biology and pathogenesis were reported and discussed. The meeting was divided into 12 sessions, with keynote speakers providing a general review of research pertinent to each one. This volume is a collection of scientific papers presented at the symposium. Once a coronavirus was recognized as the etiological agent of SARS, intensive work by many investigators resulted in determination of the sequence of the virus, engineering of reverse genetics systems, and identification of the host cell receptor used by the virus. With the increased interest in coronaviruses, new members of the family associated with human disease were identified.
Feature:
Summarizes all of the most current research in the field
The only comprehensive book covering in the field in the last 5 years
Contents:
Viral RNA Synthesis.- The Coronavirus Replicase: Insights into a Sophisticated Enzyme Machinery.- Biochemical Aspects of Coronavirus Replication.- A Previously Unrecognized Unr Stem-Loop Structure in the Coronavirus 5’ Untranslated Region Plays a Functional role in Replication.- Regulation of Coronavirus Transcription: Viral and Cellular Proteins Interacting with Transcription-Regulating Sequences.- Deubiquitinating Activity of the SARS-CoV Papain-Like Protease.- Nucleocapsid Protein Expression Facilitates Coronavirus Replication.- Non Structural Proteins 8 and 9 of Human Coronavirus 229E.- Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture.- Mutational Analysis of MHV-A59 Replicase Protein-NSP10.- The NSP2 Proteins of Mouse Hepatitis Virus and Sars Coronavirus are Dispensable for Viral Replication.- Molecular Dissection of Porcine Reproductive and Respiratory Virus Putative Nonstructural Protein 2.- Differential role of N-Terminal Polyprotein Processing in Coronavirus Genome Replication and Minigenome Amplification.- Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Subgenomic RNAs.- Identification and Characterization of a Unique Ribosomal Frameshifting Signal in SARS-CoV ORF3A.- Adp-Ribose-1”-Phosphatase Activities of the Human Coronavirus 229E and Sars Coronavirus X Domains.- Nonstructural Proteins of Human Coronavirus NL63.- MHV-A59 Orf1a Replicase Protein NSP7-NSP10 Processing in Replication.- Stem-Loop 1 in the 5’ UTR of the Sars Coronavirus can Substitute for its Counterpart in Mouse Hepatitis Virus.- Transcriptional Regulation of RNA3 of Infectious Bronchitis Virus.- Protein Synthesis, Structure, and Processing.- Structure, Expression, and Intracellular Localization of the SARS-CoV Accessory Proteins 7a and 7b.- Sumoylation of the Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus by Interaction with UBC9.- Importance of MHV-CoV A59 Nucleocapsid Protein Cooh-Terminal Negative Charges.- Expression and Structural Analysis of Infectious Bronchitis Virus Nucleoprotein.- Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response.- The Nuclear Localization Signal of the Prrs Virus Nucleocapsid Protein Modulates Viral Replication in vitro and Antibody Response in vivo.- Sars Coronavirus Accessory ORFs Encode Luxury Functions.- Production and Characterization of Monoclonal Antibodies Against the Nucleocapsid Protein of SARS-COV.- Mouse Hepatitis Coronavirus Nucleocapsid Phosphorylation.- Viral Assembly and Release.- Genetic and Molecular Biological Analysis of Protein-Protein Interactions in Coronavirus Assembly.- New Insights on the Structure and Morphogenesis of Berne Virus.- Ultrastructure of SARS-CoV, FIPV, and MHV Revealed by Electron Cryomicroscopy.- Role of Mouse Hepatitis Coronavirus Envelope Protein Transmembrane Domain.- The Transmembrane Domain of the Infectious Bronchitis Virus E Protein is Required for Efficient Virus Release.- Viroporin Activity of SARS-CoV E Protein.- Efficient Transduction of Dendritic Cells Using Coronavirus-Based Vectors.- Viral Entry.- Insights from the Association of SARS-CoV S-Protein with its Receptor, ACE2.- Attachment Factor and Receptor Engagement of Sars Coronavirus and Human Coronavirus NL63.- Interactions Between Sars Coronavirus and its Receptor.- Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein.- Fluorescence Dequenching Assays of Coronavirus Fusion.- Porcine Arterivirus Entry in Macrophages: Heparan Sulfate – Mediated Attachment, Sialoadhesin-Mediated Internalization, and a Cell-Specific Factor Mediating Virus Disassembly and Genome Release.- Enhancement of SARS-CoV Infection by Proteases.- Increased Viral Titers and Subtle Changes in Plaque Morphology Upon Passage of SARS-CoV in Cells from Different Species.- Human Coronavirus 229E can Use CD209L (L-Sign) to Enter Cells.- Intracellular Transport of the S Proteins of Coronaviruses.- Analysis of SARS-CoV Receptor Activity of ACE2 Orthologs.- Interaction Between the Spike Protein of Human Coronavirus NL63 and its Cellular Receptor ACE2.- Human Angiotensin - Converting Enzyme 2 (ACE2) is a Receptor for Human Respiratory Coronavirus NL63.- Molecular Interactions of Group 1 Coronaviruses with Feline APN.- Pseudotyped Vesicular Stomatitis Virus for Functional Analysis of Sars Coronavirus Spike Protein.- Subcellular Localization of SARS-CoV Structural Proteins.- Spike Gene Determinants of Mouse Hepatitis Virus Host Range Expansion.- Virion-Liposome Interactions Identify a Cholesterol-Independent Coronavirus Entry Stage.- Avian Infectious Bronchitis Virus Enters Cells Via the Endocytic Pathway.- Three-Dimensional Reconstruction of the Nucleolus Using Meta-Confocal Microscopy in Cells Expressing the Coronavirus Nucleoprotein.- Dissection of the Fusion Machine of Sars-Coronavirus.- Characterization of Persistent SARS-CoV Infection in Vero E6 Cells.- Receptor-Independent Spread of a Neurotropic Murine Coronavirus MHV-JHMv in Mixed Neural Culture.- Receptor-Independent Infection of Mouse Hepatitis Virus: Analysis by Spinoculation.- SARS-CoV, But not HCoV-NL63, Utilizes Cathepsins to Infect Cells: Viral Entry.- Pathogenesis of Non-Human Coronaviruses.- Coronavirus Immunity: From T Cells to B Cells.- RAT Coronavirus Infection of Primary RAT Alveolar Epithelial Cells.- Infectious Bronchitis Coronavirus Induces Cell-Cycle Perturbations.- Genes 3 and 5 of Infectious Bronchitis Virus are Accessory Protein Genes.- NKG2D Signaling and Host Defense after Mouse Hepatitis Virus Infection of the Central Nervous System.- Murine Hepatitis Virus Strain 1 as a Model for Severe Acute Respiratory Distress Syndrome (Sars).- Persistent Coronavirus Infection of Progenitor Oligodendrocytes.- CD8+ T-Cell Priming During a Central Nervous System Infection with Mouse Hepatitis Virus.- Antibody-Mediated Virus Clearance from Neurons of Rats Infected with Hemagglutinating Encephalomyelitis Virus.- Developing Bioinformatic Resources for Coronaviruses.- Autoantibodies Exacerbate the Severity of MHV-Induced Encephalitis.- Analysis of the N Protein in Feline Coronavirus Strains in Italy.- Differential Induction of Proinflammatory Cytokines in Primary Mouse Astrocytes and Microglia by Coronavirus Infection.- Preferential Infection of Mature Dendritic Cells by the JHM Strain of Mouse Hepatitis Virus.- Role of the Replicase Gene of Murine Coronavirus JHM Strain in Hepatitis.- Identification of the Receptor for FGL2 and Implications for Susceptibility to Mouse Hepatitis Virus (MHV-3)-Induced Fulminant Hepatitis.- Pathogenesis of Arteriviruses and Toroviruses.- Equine Viral Arteritis.- Use of a PRRSV Infectious Clone to Evaluate in Vitro Quasispecies Evolution.- Gamma-Interferon Involvement in the Pathogenesis of Lactate Dehydrogenase–Elevating Virus Infection.- Replication and Expression Analysis of PRRSV Defective RNA.- Efficacy of an Inactivated PRRSV Vaccine: Induction of Virus-Neutralizing Antibodies and Partial Virological Protection upon Challenge.- Pathogenesis of Human Coronaviruses.- Sars and Other Coronaviruses in Humans and Animals.- Animal Models for Sars.- HCoV-Oc43–Induced Apoptosis of Murine Neuronal Cells.- Infection of Human Airway Epithelia by Sars Coronavirus is Associated with ACE2 Expression and Localization.- Human Coronavirus NL63 Infection is Associated with Croup.- A SARS-CoV–Specific Protein Enhances Virulence of an Attenuated Strain of Mouse Hepatitis Virus.- Genetic Evolution of Human Coronavirus OC43 in Neural Cell Culture.- Synergistic Inhibition of Sars-Coronavirus Replication by Type I and Type II IFN.- Mustela Vison ACE2 Functions as a Receptor for Sars-Coronavirus.- HCoV-229E Infects and Activates Monocytes.- Pathological and Virological Analyses of Severe Acute Respiratory Syndrome–Associated Coronavirus Infections in Experimantal Animals.- Identification of Ferret ACE2 and its Receptor Function for Sars-Coronavirus.- Human Coronavirus-NL63 Infection is not Associated with Acute Kawasaki Disease.- Toward the Development of an Infectious cDNA Clone of a Human Enteric Coronavirus.- HCoV-OC43–Induced Encephalitis is in Part Immune-Mediated.- Sars Cov Replication and Pathogenesis in Human Airway Airway Epithelial Cultures.- Immunogenicity of SARS-CoV: the Receptor-Binding Domain of S Protein is a Major Target of Neutralizing Antibodies.- Glia Expression of MHC During CNS Infection by Neurotropic Coronavirus.- Resurrection of an “Extinct” SARS-CoV Isolate GD03 from LATE 2003.- Vaccines, Antiviral Drugs, and Diagnostics.- Sars Coronavirus Vaccine Development.- Development of Vaccines and Passive Immunotherapy Against Sars Coronavirus Using Mouse and Scid-PBL/hu Mouse Models.- Inhibition and Escape of SARS-CoV Treated with Antisense Morpholino Oligomers.- Validation of Coronavirus E Proteins Ion Channels as Targets for Antiviral Drugs.- Identification of Essential Genes as a Strategy to Select a Sars Candidate Vaccine Using a SARS-CoV Infectious cDNA.- Structure and Dynamics of Sars Coronavirus Main Proteinase (MPRO).- Highly Attenuated Vaccinia Virus Dis as a Potential Sars Vaccine.- Renilla Luciferase as a Reporter to Assess SARS-CoV mRNA Transcription Regulation and Efficacy of ANTI-SARS-CoV Agents.- Virucidal Effect of a Newly Developed Nickel Alloy on Mouse Coronavirus.- Construction of a Full-Length cDNA Infectious Clone of a European-Like Type 1 PRRSV Isolated in the U.S..- Identification and Evaluation of Coronavirus Replicase Inhibitors Using a Replicon Cell Line.
PRODUCT DETAILS
Publisher: Springer (Springer US)
Publication date: August, 2006
Pages: 618
Weight: 1140g
Availability: Not available (reason unspecified)
Subcategories: Epidemiology, Immunology, Infectious Diseases, Microbiology, Pathology
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