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Main description:
Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the "magic bullet" that would allow the specific destruction of neoplastic cells. H- ever, many years' effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is once again attracting scientists and clinicians. There are several reasons for the renewed optimism; certainly the expe- ence of the last two decades has provided a wealth of information about problems associated with antibody therapy, and possible solutions to these problems. Recombinant antibody engineering has rejuvenated the field, allowing both the modification of antibodies to improve their in vivo pr- erties and the isolation of novel antibody molecules by such techniques as phage display. The results of recent clinical trials have demonstrated unequivocally the benefit of antibody therapy in a number of settings, and, finally, more careful consideration has been taken of the types of disease best treated using this approach.
Contents:
Part I. Introduction. The Antibody Molecule, Andrew J. T. George. Polyclonal and Monoclonal Antibodies, Mary A. Ritter. Engineering Antibody Molecules, Rakesh Verma and Ekaterini Boleti. Phage Display Technology, Michael Johns. Part II. Antibodies in Medicine. Prospects for the Application of Antibodies in Medicine, Herman Waldmann. Antibodies for Neoplastic Disease: Solid Tumors, Ian T. W. Matthews. The Application of Monoclonal Antibodies in the Treatment of Lymphoma, Martin J. Glennie, Jamie Honeychurch, Ruth R. French, and Alison L. Tutt. Antibodies for Inflammatory Disease: Effector Cells, Richard Smith. Antibodies for Inflammatory Disease: Cytokines, Peter C. Taylor. Antibodies for Transplantation, Denise L. Faustman. Antibody-Based Therapies in Infectious Diseases, H. Barbaros Oral and Cezmi A. Akdis. Antibodies in Nuclear Medicine, A. Michael Peters. Animal Models for Tumor Localization, Gail Rowlinson-Busza. Antibodies for Immunoassays, David J. Newman. Part III. Ethics and Industry. Intellectual Property, William M. Brown. From Laboratory to Clinic: The Story of CAMPATH-1, Geoff Hale and Herman Waldmann. Part IV. Production and Purification. Production of Monoclonal Antibodies, Jona Freysdottir. Purification of Monoclonal Antibodies Using Protein A/G, Bridget Heelan. Preparation of Monoclonal Antibodies Using Ion Exchange Chromatography, Maureen Power. Quality Control of Raw Materials, Patrick Harrison and Geoff Hale. Cell Banks and Stability of Antibody Production, Pru Bird and Geoff Hale. Measurement of Endotoxin, Jenny Phillips, Patrick Harrison, and Geoff Hale. Aseptic Vial Filling, Kuldip Bhamra, Patrick Harrison, and Geoff Hale. Measurement of Antibody Concentrations by Hemagglutination, Jenny Phillips and Geoff Hale. Part V. Modification of Antibodies. Enzymatic Digestion of Monoclonal Antibodies, Sarah M. Andrew. How to Make Bispecific Antibodies, Ruth R. French. Radiolabeling Monoclonal Antibodies, Calvin S. R. Gooden. Determination of theImmunoreactivity of Radiolabeled Monoclonal Antibodies, Gail Rowlinson-Busza. Use of Biosensors to Measure the Kinetics of Antibody-Antigen Interactions, Andrew J. T. George. Part VI. Application of Antibodies In Vitro. How to Set Up an ELISA, Bill Jordan. Measurement of HAMA and Anti-Idiotypic Antibodies, Steve Nicholson. SDS-PAGE and Western Blotting, Abdulhamid A. Al-Tubuly. Flow Cytometric Analysis, Paul F. McKay. Immunocytochemistry, Susan Van Noorden. Immunolabeling for Electron Microscopy, Catherine E. Sarraf. Part VII. Antibody Engineering. PCR of the V-Region, Rakesh Verma. Phage Display Technology: Protocols, Michael Johns and Donald B. Palmer. Index.
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 492
Weight: 717g
Availability: Available
Subcategories: Immunology
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