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MORE ABOUT THIS BOOK
Main description:
This book is about melanoma-its biology, immunology, and pathology, as well as the initial use of powerful genomic tools to study its fundamental mole- lar and genetic characteristics. The study of cancer will be profoundly impacted by the Human Genome Project. I would like to discuss some of these changes. The first draft of the human genome sequence was announced in June 2000, and we have just scratched the surface of the changes it will engender in medicine. A relevant question is what are the long-term effects of the Human Genome Project for medicine? I would argue that there are three, and each of these three point toward the view that systems biology will dominate biology and medicine of the 21st century. First, the Human Genome Project introduced a new type of s- ence-discovery science. Discovery science takes a biological system (e. g. , the genome) and defines all of its elements (e. g. , the sequences of the 24 human ch- mosomes). Thus, it creates a rich infrastructure from which the classical hypo- esis-driven science can be done more effectively. The effective integration of discovery- and hypothesis-driven science is a key for systems approaches to bi- ogy and medicine. Second, the Human Genome Project has provided a "periodic table of life.
Contents:
Part I. Biology
The Many Molecular Mysteries of Melanoma
Brian J. Nickoloff
Isolation of Tumor Suppressor Genes in Melanoma by cDNA Microarray
Yan A. Su and Jeffrey M. Trent
Molecular Characterization of Melanoma-Derived Antigens
Marten Visser, Markwin P. Velders, Michael P. Rudolf, and W. Martin Kast
Experimental Induction of Human Atypical Melanocytic Lesions and Melanoma in Ultraviolet-Irradiated Human Skin Grafted to Immunodeficient Mice
Carola Berking and Meenhard Herlyn
Dissection of Immunosuppressive Effects of Ultraviolet Radiation
Stephen E. Ullrich and David A. Schmitt
Antisense Oligonucleotides as Research Tools
Jennifer K. Taylor, Scott R. Cooper, and Nicholas M. Dean
Part II. Diagnosis
Genetic Testing in Familial Melanoma: Epidemiologic/Genetic Assessment of Risks and Role of CDKN2A Analysis
David Hogg, Ling Liu, and Norman Lassam
Role of Molecular Biology in Diagnostic Pathology of Melanoma
Andrzej Slominski, Andrew Carlson, Jacobo Wortsman, and Martin C. Mihm
Identification of Altered Gene Expression Associated with Pigmentary Lesions by Differential Display Analysis
I. Caroline Le Poole and Thomas L. Brown
Fluorescence In Situ Hybridization as a Tool in Molecular Diagnostics of Melanoma
Lionel J. Coignet
Part III. Treatment
Antigen-Pulsed Dendritic Cell Approach to Melanoma
Frank O. Nestle, Adrian Tun-Kyi, and Michel F. Gilliet
Gene Therapy in Melanoma
Giorgio Parmiani, Flavio Arienti, Cecilia Melani, Filiberto Belli, Gianfrancesco Gallino, and Arabella Mazzocchi
Use of Gene Gun for Genetic Immunotherapy: In Vitro and In Vivo Methods
Alfred E. Chang, Keishi Tanigawa, Joel C. Turner, Edwin C. Chang, and Hua Yu
Role of Cytokines in Pathology of Melanoma and Use of Biologic Response Modifiers in Melanoma
JosephI. Clark
Surgical Techniques for Treatment of Primary Cutaneous Melanoma
June K. Robinson
Part IV. Monitoring
Utility of Fine-Needle Aspiration Biopsy for Prospective Analysis of Patients Undergoing Therapy for Metastatic Melanoma
Adam I. Riker
A Molecular Technique Useful in the Detection of Occult Metastases in Patients with Melanoma: RT-PCR Analysis of Sentinel Lymph Nodes and Peripheral Blood
James S. Goydos and Douglas S. Reintgen
Immunoscope Analysis of T-Lymphocytes Infiltrating Melanocytic Tumors
Philippe Musette, Jos Even, Louis Dubertret, Philippe Kourilsky, and Gabriel Gachelin
T-Cell Receptor Clonotype Mapping Using Denaturing Gradient Gel Electrophoresis: Analysis of Clonal T-Cell, Responses in Melanoma
Per thor Straten, Jurgen C. Becker, Jesper Zeuthen, and Per Guldberg
Methods for Use of Peptide-MHC Tetramers in Tumor Immunology
Cassian Yee and Peter P. Lee
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2011
Pages: 382
Weight: 572g
Availability: Available
Subcategories: Oncology
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