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MORE ABOUT THIS BOOK
Main description:
Since the first recognition of outbreaks of cerebrospinal or spotted fever at the end of the nineteenth and the beginning of the twentieth centuries, the menace of the meningococcus has been high on the list of public health prio- ties. Few if any pathogens surpass the meningococcus in the rapidity and sev- ity with which it devastates previously healthy individuals. The challenge of understanding the biology of this fascinating microbe is immense, but few will doubt that successful control of meningococcal meningitis and septicemia will only transpire through the application of a body of extraordinary detailed inf- mation, including key minutiae of its molecular biology. In the first of two companion volumes, Meningococcal Vaccines, the team of experts gathered by Andy Pollard and Martin Maiden converge to p- vide an impressive accumulation of molecular tools with which to lay bare the secrets of the meningococcus. The results of this ambitious and welcome v- ume represent an exciting and much needed resource for all of us in the field.
Contents:
Meningococcal Vaccines and Vaccine Developments
Ian M. Feavers
Immune Response and Host-Pathogen Interactions
Andrew J. Pollard and David Goldblatt
Purification of Capsular Polysaccharide
Qingling Yang and Harold Jennings
Protein-Polysaccharide Conjugation
Zhongwu Guo and Harold Jennings
N-Propionylation
Zhongwu Guo and Harold Jennings
Outer Membrane Protein Purification,
armen Arigita, Wim Jiskoot, Matthijs R. Graaf, and Gideon F. A. Kersten
Outer Membrane Protein Vesicle Vaccines for Meningococcal Disease
Carl E. Frasch, Loek van Alphen, Johan Holst, Jan T. Poolman, and Einar Rosenqvist
Methods for Manipulation of Transferrin-Binding Proteins
Leanne M. DeWinter and Anthony B. Schryvers
Methods for the Preparation and Crystallization of Fab Fragments in Complex with Peptide Antigens Derived from N. meningitidis Outer Membrane Proteins
Richard F. Collins and Jeremy P. Derrick
Application of Optical Biosensor Techniques to the Characterization of PorA-Antibody Binding Kinetics
Janet Suker and Bambos M. Charalambous
Construction of porA Mutants
Peter van der Ley and Loek van Alphen
Construction of LPS Mutants
Peter van der Ley and Liana Steeghs
Recombinant Proteins in Vaccine Development
Myron Christodoulides, Keith A. Jolley, and John E. Heckels
Identification of Peptides that Mimic N. meningitidis LOS Epitopes Via the Use of Combinatorial Phage-Display Libraries
Paul J. Brett, Ian M. Feavers, and Bambos M. Charalambous
Testing Meningococcal Vaccines for Mitogenicity and Superantigenicity
Alexei A. Delvig, John H. Robinson, and Lee Wetzler
Early Experiences with Nasal Vaccines against Meningococcal Disease
Johan Holst and Bjorn Haneberg
Animal Models for Meningococcal Disease
Andrew R. Gorringe, Karen M.Reddin, Pierre Voet, and Jan T. Poolman
Determination of Antibody Responses to Meningococcal Antigens by ELISA
Einar Rosenqvist, Helena Kayhty, and Andrew J. Pollard
Immunoblot Analysis of Sera from Patients and Vaccinees
Elisabeth Wedege
Serogroup B and C Serum Bactericidal Assays
Ray Borrow and George M. Carlone
A Modified ELISA for Measurement of High-Avidity IgG Antibodies to Meningococcal Serogroup C Polysaccharide that Correlate with Bactericidal Titers
Dan M. Granoff and John J. Donnelly
Whole-Blood Model
Catherine A. Ison
Antibody-Induced Opsonophagocytosis of Serogroup B Meningococci Measured by Flow Cytometry
Terje E. Michaelsen and Audun Aase
T-Cell Responses Against Meningococcal Antigens
Lisbeth Meyer Naess, Fredrik Oftung, Audun Aase, Terje E. Michaelsen and Andrew J. Pollard
CD4 T-Cell Epitope Mapping
Alexei A. Delvig and John H. Robinson
Epitope Mapping
John E. Heckels and Myron Christodoulides
Meningococcal Vaccine Trials
Paddy Farrington and Elizabeth Miller
The Introduction of Group C Conjugate Meningococcal Vaccine into the UK
David M. Salisbury
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2013
Pages: 421
Weight: 640g
Availability: Available
Subcategories: Infectious Diseases
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