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Main description:
Internationally recognized investigators review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, and by analogy suggests possible research techniques for the more common proteinopthies, such as Alzheimer's and Parkinson's diseases.
Contents:
What Would Thomas Henry Huxley Have Made of Prion Diseases?
Rosalind M. Ridley
Prion Protein as Copper-Binding Protein at the Synapse
Hans A. Kretzschmar, Tobias Tings, Axel Madlung, Armin Giese, and Jochen Herms
A Function for the Prion Protein?
David R. Brown and Ian M. Jones
Prion Protein Peptide: Agents of Death for Neurons
David R. Brown
Characterization of Bovine Spongiform Encephalopathy and Scrapie Strains/Isolates by Immunochemical Analysis of PrPSc
Martin H. Groschup, Frauke Junghans, Martin Eiden, and Thorsten Kuczius
Differential Targeting of Neurons by Prion Strains
Stephen J. DeArmond
Transgenic Studies of Prion Diseases
Glenn C. Telling
Prions: From Neurografts to Neuroinvasion
Markus Glatzel, Sebastian Brandner, Michael A. Klein, and Adriano Aguzzi
Cellular and Transgenic Models of Familial Prion Diseases
David A. Harris, Roberto Chiesa, Antonio Migheli, Pedro Piccardo, and Bernardino Ghetti
Central Nervous System Inflammation and Prion Disease Pathogenesis
Samar Betmouni and V. Hugh Perry
The Electroneuropathology of Prion Disease
J. Richard Greene
Transmissible Spongiform Encephalopathy Neurobiology and Ultrastructure Suggests Extracellular PrPSc Conversion Consistent with Classical Amyloidosis
Martin Jeffrey and Jan R. Fraser
Conformation as Therapeutic Target in the Prionoses and Other Neurodegenerative Conditions
Thomas Wisniewski, Einar M. Sigurdsson, Pierre Aucouturier, and Blas Frangione
Prions of Yeast: From Cytoplasmic Genes to Heritable Amyloidosis
Reed B. Wickner, Herman K. Edskes, Kimberly L. Taylor, Marie-Lise Maddelein, Hiromitsu Moriyama, and B. Tibor Roberts
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 292
Weight: 478g
Availability: Available
Subcategories: Pathology
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