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MORE ABOUT THIS BOOK
Main description:
With sequencing of the human genome now complete, deciphering the role of gene function in human neurological pathophysiology is a promise that has yet to be realized. More than most diseases, stroke has been keenly studied from a genomic perspective. Studies are numerous and incorporate data on stroke inheritance, chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain injury, repair, and recovery. The problem is no longer a lack of information but one of interpretation and prioritization of what we do know. The aims of Stroke Genomics: Methods and Reviews are twofold. First, it aims to provide the reader with cutting-edge reviews of clinical and preclinical genomics, written by leading experts in the field. In particular, the authors of certain chapters relate gene expression changes to physiological end points, such as functional imaging paradigms. Thus, a more holistic approach to gene expression is described, one in which molecular biology goes hand in hand with stroke pathophysiology. Second, detailed methods for study of the molecular biology of stroke are (TM) also included. Following the format of the Methods in Molecular Medicine series, these chapters will enable the reader to employ each technique without recourse to other methods texts. In its entirety, this book should provide the reader with the knowledge needed to design, execute, and interpret preclinical and clinical studies of stroke genomics.
Contents:
Part I. Introduction
Introduction to Stroke Genomics
Simon J. Read and Frank C. Barone
Part II. Preclinical Models and Gene Manipulation
Choice, Methodology, and Characterization of Focal Ischemic Stroke Models: The Search for Clinical Relevance
David Virley
Mutant Animal Models of Stroke and Gene Expression: The Stroke-Prone Spontaneously Hypertensive Rat
Hilary V. O. Carswell, Martin W. McBride, Delyth Graham, Anna F. Dominiczak, and I. Mhairi Macrae
Gene Therapy in Neurological Disease
Midori A. Yenari and Robert M. Sapolsky
Stem Cell Transplantation After Middle Cerebral Artery Occlusion
Paul Stroemer and Helen Hodges
Endogenous Brain Protection: Models, Gene Expression, and Mechanisms
Frank C. Barone
Production of Transgenic and Mutant Mouse Models
Alex J. Harper
3-Nitropropionic Acid Model of Metabolic Stress: Assessment by Magnetic Resonance Imaging
Toby John Roberts
Part III. Clinical Paradigms
Practicalities of Genetic Studies in Human Stroke
Ahamad Hassan and Hugh S. Markus
Evaluation of the Interactions of Common Genetic Mutations in Stroke
Zoltan Szolnoki
Part IV. Assessing Differential Expression
Technologies of Disease-Related Gene Discovery Using Preclinical Models of Stroke
Xinkang Wang
Quantitative Analysis of Gene Transcription in Stroke Models Using Real-Time RT-PCR
David C. Harrison and Brian C. Bond
Effective Analysis of Genomic Data
Paul R. Nelson, Andrew B. Goulter, and Richard J. Davis
Bioinformatic Approaches to Assigning Protein Function From Novel Sequence Data
David Michalovich and Richard Fagan
Pragmatic Target Discovery From Novel Gene to Functionally Defined Drug Target: The Interleukin-1 Story
Stuart McRae Allan
Indexf
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 361
Weight: 618g
Availability: Available
Subcategories: Neuroscience
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