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Main description:
Parkinson's disease is a progressive neurodegenerative disorder charact- ized clinically by tremor, rigidity, slow movements, and postural instability. Pathologically, dopaminergic neurons of the substantia nigra bear the brunt of the degeneration, though other neuronal groups can be affected as well. Although Parkinson's disease is the only neurodegenerative disorder for which effective therapies are available, these treatment options are only symptomatic, do not influence the underlying degenerative process, and are associated with a high incidence of complications, particularly with their long-term use. The progressive nature of the disease and the limitations of its palliative therapies result in significant functional impairment. The chronic disability and the increased prevalence of the disease with the prolongation of life expectancy in developed countries make the social and economic impact of this disease quite high. For- nately, systematic basic and clinical research in this disease has yielded major new advances that render patients' hopes for a cure considerably closer to reality. The application of molecular biologic methodologies in the study of Parkinson's disease has begun to have a major impact only in recent years. Con- quently, the utility of these technologies is largely in the research arena, although their clinical applications are now being realized.
Contents:
Part I. Genetics
Point Mutations in the _-Synuclein Gene
Abbas Parsian and Joel S. Perlmutter
Autosomal Recessive Juvenile Parkinsonism (AR-JP): Genetic Diagnosis
Hiroto Matsumine, Nobutaka Hattori, and Yoshikuni Mizuno
Part II. Molecular Pathogenetic Studies
Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy as _-Synucleinopathies
Michel Goedert, Ross Jakes, R. Anthony Crowther, and Maria Grazia Spillantini
_-Synuclein/Amyloid Interactions
Poul Henning Jensen
Functional Defect Conferred by the Parkinson's Disease-Causing _-Synuclein (Ala30Pro) Mutation
Poul Henning Jensen
Molecular Biology of Dopamine-Induced Apoptosis: Possible Implications for Parkinson's Disease
Ilan Ziv, Anat Shirvan, Daniel Offen, Ari Barzilai, and Eldad Melamed
Animal Models of Induced Apoptotic Death in the Substantia Nigra
Tinmarla F. Oo and Robert E. Burke
Apoptotic Morphology in Phenotypically Defined Dopaminergic Neurons of the Substantia Nigra
Tinmarla F. Oo and Robert E. Burke
The Role of Nitric Oxide in Parkinson's Disease
Serge Przedborski and Ted M. Dawson
Oxidative Stress Indices in Parkinson's Disease: Biochemical Determination
Moussa B. H. Youdim, Noam Drigues, and Silvia Mandel
Part III. Molecular Aspects of Basal Ganglia Function
Quantification of Tyrosine Hydroxylase mRNA
Hiroshi Ichinose, Tamae Ohye, Takahiro Suzuki, Hidehito Inagaki, and Toshiharu Nagatsu
Immunochemical Analysis of Dopamine Transporters in Parkinson's Disease
Gary W. Miller and Allan I. Levey
Dopamine Transporter and Vesicular Monoamine Transporter Knockout Mice: Implications for Parkinson's Disease
Gary W. Miller, Yan-Min Wang, Raul R. Gainetdinov, and Marc G. Caron
Transcription Mechanisms for Dopamine Receptor Genes
Sang-Hyeon Lee and M. Maral Mouradian
Detection of DNA/Protein Interactions in Dopamine Receptor Genes
Sang-Hyeon Lee and M. Maral Mouradian
In Situ Hybridization on Brain Tissue
Claas-Hinrich Lammers, Yoshinobu Hara, and M. Maral Mouradian
Regulation of Striatal N-Methyl-d-Aspartate Receptor (NMDAR) Function by Phosphorylation of Its Subunits in Parkinsonian Rats
Justin D. Oh
Part IV. Molecular Therapies
Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism
Richard Grondin, Zhiming Zhang, Dennis D. Elsberry, Greg A. Gerhardt, and Don M. Gash
Grafting Genetically Engineered Cells into the Striatum of NonHuman Primates
Krys S. Bankiewicz, Phillip Pivirotto, Rosario Sanchez-Pernaute, and Eugene O. Major
Encapsulated Cell Implants as a Novel Treatment for Parkinson's Disease
Jack L. Tseng and Patrick Aebischer
Neural Stem Cell Technology as a Novel Treatment for Parkinson's Disease
Richard J. E. Armstrong, Anne E. Rosser, Stephen B. Dunnett, and Roger A. Barker
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2011
Pages: 336
Weight: 487g
Availability: Available
Subcategories: Neurology
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