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Main description:
This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer-both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher.
Contents:
Part I. Introduction
Molecular and Genetic Aspects of Lung Cancer
William N. Rom and Kam-Meng Tchou-Wong
Part II. Detection of Altered Tumor Markers in Clinical Samples for Diagnosis and Prognosis
A. Molecular Methods for Prognostic Detection of Altered Tumor Markers: Clinical Implications
Molecular Alterations in Lung Cancer: Impact on Prognosis
Takashi Kijima, Gautam Maulik, and Ravi Salgia
Cellular Predictive Factors of Drug Resistance in Non-Small Cell Lung Carcinomas
Manfred Volm, Reet Koomagi, and Werner Rittgen
Clinical Implications of p53 Mutations in Lung Cancer
Barbara G. Campling and Wafik S. El-Deiry
An Epidemiologic and Clinicopathologic Overview of AIDS-Associated Pulmonary Kaposi's Sarcoma
David M. Aboulafia
Myeloperoxidase Promoter Region Polymorphism and Lung Cancer Risk
Xifeng Wu, Matthew B. Schabath, and Margaret R. Spitz
Clinical Utility of Tumor Markers in the Management of Non-Small Cell Lung Cancer
Dennis E. Niewoehner and Jeffrey B. Rubins
B. Molecular Methods for Prognostic Detection of Altered Lung Tumor Markers in Clinical Samples
I. DNA-Based Analysis. Detection of Chromosomal Aberrations in Lung Tissue and Peripheral Blood Lymphocytes Using Interphase Fluorescence In Situ Hybridization (FISH)
Randa A. El-Zein and Sherif Z. Abdel-Rahman
In Situ Analysis of Telomerase RNA Gene Expression as a Marker for Tumor Progression
W. Nicol Keith
A High-Throughput Methodology for Identifying Molecular Targets Overexpressed in Lung Cancers
Tongtong Wang and Steven G. Reed
Expression Profiling of Lung Cancer Based on Suppression Subtraction Hybridization (SSH)
Simone Petersen and Iver Petersen
Comparative Genomic Hybridization of Human Lung Cancer
Iver Petersen
Sensitive Assays for Detection of Lung Cancer: MolecularMarkers in Blood Samples
Marcia V. Fournier, Katherine J. Martin, Edgard Graner, and Arthur B. Pardee
Fluorescent Microsatellite Analysis in Bronchial Lavage as a Potential Diagnostic Tool for Lung Cancer
John K. Field and Triantafillos Liloglou
Southern Blotting of Genomic DNA from Lung and Its Tumors: Application to Analysis of Allele Loss on Chromosome 11p15.5
Diana M. Pitterle and Gerold Bepler
Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk
Xifeng Wu, He Yu, Nimisha Makan, and Margaret R. Spitz
II. PCR-Based Analyses. Comparative Multiplex PCR and Allele-Specific Expression Analysis in Human Lung Cancer: Tools to Facilitate Target Identification
Jim Heighway, Daniel Betticher, Teresa Knapp, and Paul Hoban
Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT
Veerle A. M. C. Somers and Frederick B. J. M. Thunnissen
Detection of K-ras and p53 Mutations by 'Mutant-Enriched' PCR-RFLP
Marcus Schuermann
Detection of Small Cell Lung Cancer by RT-PCR for Neuropeptides, Neuropeptide Receptors, or a Splice Variant of the Neuron Restrictive Silencer Factor
Judy M. Coulson, Samreen I. Ahmed, John P. Quinn, and Penella J. Woll
III. Immunohistochemical Analyses
Utilization of Thyroid Transcription Factor-1 Immunostaining in the Diagnosis of Lung Tumors
Nelson G. Ordonez
Molecular Biologic Substaining of Stage I NSCLC Through Immunohistochemistry Performed on Formalin-Fixed, Paraffin-Embedded Tissue
Mary-Beth Moore Joshi, Thomas A. D'Amico, and David H. Harpole, Jr
A Sensitive Immunofluorescence Assay for Detection of p53 Protein in the Sputum
Zumei Feng, Defa Tian, and Radoslav Goldman
SPR1: An Early Molecular Marker for Bronchial Carcinogenesis
Derick Lau, Linlang Guo, Andrew
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2013
Pages: 815
Weight: 1270g
Availability: Available
Subcategories: Oncology
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