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Main description:
The natural, biological, medical, and related sciences would not be what they are today without the microscope. After the introduction of the optical microscope, a second breakthrough in morphostructural surface analysis occurred in the 1940s with the development of the scanning electron microscope (SEM), which, instead of light (i. e. , photons) and glass lenses, uses electrons and electromagnetic lenses (magnetic coils). Optical and scanning (or transmission) electron microscopes are called "far-field microscopes" because of the long distance between the sample and the point at which the image is obtained in comparison with the wavelengths of the photons or electrons involved. In this case, the image is a diffraction pattern and its resolution is wavelength limited. In 1986, a completely new type of microscopy was proposed, which, without the use of lenses, photons, or electrons, directly explores the sample surface by means of mechanical scanning, thus opening up unexpected possibilities for the morphostructural and mechanical analysis of biological specimens. These new scanning probe microscopes are based on the concept of near-field microscopy, which overcomes the problem of the limited diffraction-related resolution inherent in conventional microscopes. Located in the immediate vicinity of the sample itself (usually within a few nanometers), the probe records the intensity, rather than the interference signal, thus significantly improving resolution. Since the most we- known microscopes of this type operate using atomic forces, they are frequently referred to as atomic force microscopes (AFMs).
Contents:
Part I. The Basics of Atomic Force Microscopy
How the Atomic Force Microscope Works
Davide Ricci and Pier Carlo Braga
Imaging Methods in Atomic Force Microscopy
Davide Ricci and Pier Carlo Braga
Recognizing and Avoiding Artifacts in AFM Imaging
Davide Ricci and Pier Carlo Braga
Advanced Biosensing Using Micromechanical Cantilever Arrays
Martin Hegner and Youri Arntz
Part II. Morphostructural Analysis of Cellular Structures
Analysis of Human Fibroblasts by Atomic Force Microscopy
Gillian R. Bushell, Colm Cahill, Sverre Myhra, and Gregory S. Watson
Corneal Tissue Observed by Atomic Force Microscopy
Stylliani Lydataki, Miltiadis K. Tsilimbaris, Eric S. Lesniewska, Alain Bron, and Iannis G. Pallikaris
AFM Study of Surface Structure Changes in Mouse Spermatozoa Associated With Maturation
Hiroko Takano and Kazuhiro Abe
Calculation of Cuticle Step Heights from AFM Images of Outer Surfaces of Human Hair
James R. Smith
Imaging Living Chondrocyte Surface Structures With AFM Contact Mode
Gerlinde Bischoff, Anke Bernstein, David Wohlrab, and Hans-Joachim Hein
Growth Cones of Living Neurons Probed by Atomic Force Microscopy
Davide Ricci, Massimo Grattarola, and Mariateresa Tedesco
Evaluating Demineralization and Mechanical Properties of Human Dentin With AFM
Grayson W. Marshall, Jr., Sally J. Marshall, Mehdi Balooch, and John H. Kinney
Applying Atomic Force Microscopy to Studies in Cardiac Physiology
Jason J. Davis, Trevor Powell, and H. Allen O. Hill
Imaging Bacterial Shape, Surface, and Appendages Before and After Treatments With Antibiotics
Pier Carlo Braga and Davide Ricci
Part III. Subcellular Structures Investigation
Visualizing Nuclear Structure In Situ by Atomic Force Microscopy
Luis Felipe Jimenez-Garcia and Maria de Lourdes Segura-Valdez
Imaging Surface andSubmembranous Structures in Living Cells With the Atomic Force Microscope: Notes and Tricks
Filip Braet and Eddie Wisse
Atomic Force Microscopy of Protein Complexes
Olga I. Kiselyova and Igor V. Yaminsky
Atomic Force Microscopy of Interfacial Monomolecular Films of Pulmonary Surfactant
Kaushik Nag, Robert R. Harbottle, Amiyo K. Panda, and Nils O. Petersen
High-Resolution Analysis of the 3D Organization of Human Metaphase Chromosomes
Stefan Thalhammer, Pietro Gobbi, Mirella Falconi, Giovanni Mazzotti, and Wolfgang M. Heckl
Shape and Volume of Living Aldosterone-Sensitive Cells Imaged With the Atomic Force Microscope
Stefan W. Schneider, Rainer Matzke, Manfred Radmacher, and Hans Oberleithner
Localization of Epithelial Sodium Channels by Atomic Force Microscopy
Peter R. Smith and Dale J. Benos
High-Resolution Imaging of Bacteriorhodopsin by Atomic Force Microscopy
Dimitrios Fotiadis and Andreas Engel
Part IV. Functional Investigations With AFM
Measurement of Mechanical Properties of Intact Endothelial Cells in Fresh Arteries
Hiroshi Miyazaki and Kozaburo Hayashi
Observation of Oxidative Stress on Yeast Cells
Ricardo de Souza Pereira
Lymphoblastoid Cells Exposed to Low-Frequency Magnetic Fields: Study by Atomic Force Microscopy
Settimio Grimaldi, Marco Girasole, and Antonio Cricenti
Sample Preparation Method for Observing RNA Polymerase Activity by Atomic Force Microscopy
Sandor Kasas
Atomic Force Microscopy of b-Amyloid: Static and Dynamic Studies of Nanostructure and Its Formation
Justin Legleiter and Tomasz Kowalewski
How to Build Up Biosensors With the Cantilever of the Atomic Force Microscope
Ricardo de Souza Pereira
Measurement of Single Molecular Interactions by Dynamic Force Microscopy
Martin Hegner, Wilfried Grange, and Patricia Bertoncini
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2013
Pages: 394
Weight: 601g
Availability: Available
Subcategories: Biochemistry
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