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Main description:
Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success.
The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.
Contents:
I. Design of Structural Elementary Motifs
Structure and Stability of the a-Helix: Lessons for Design
Neil Errington, Teuku Iqbalsyah, and Andrew J. Doig
De novo Design of Monomeric b-Hairpin and b-Sheet Peptides
David Pantoja-Uceda, Clara M. Santiveri, and M. Angeles Jimenez
De novo Proteins From Binary-Patterned Combinatorial Libraries
Luke H. Bradley, Peter P. Thumfort, and Michael H. Hecht
Non-Protein Amino Acids in the Design of Secondary Structure Scaffolds
Radhakrishnan Mahalakshmi and Padmanabhan Balaram
Design and Synthesis of b-Peptides With Biological Activity
Marc J. Koyack and Richard P. Cheng
II. Design of Entire Proteins and Protein Complexes
Design of Miniproteins by the Transfer of Active Sites Onto Small-Size Scaffolds
Francois Stricher, Loic Martin, and Claudio Vita
Consensus Design as a Tool for Engineering Repeat Proteins
Tommi Kajander, Aitziber L. Cortajarena, and Lynne Regan
Multiple Sequence Alignment as a Guideline for Protein Engineering Strategies
Alan R. Davidson
Sequence Search Methods and Scoring Functions, for the Design of Protein Structures
Hocine Madaoui, Emmanuelle Becker, and Raphael Guerois
Prediction of Protein-Protein Interaction Based on Structure
Gregorio Fernandez-Ballester and Luis Serrano
Electrostatic Design of Protein-Protein Association Rates
Gideon Schreiber, Yossi Shaul, and Kay E. Gottschalk
III. Design of Amyloidogenic Polypeptides and Amyloid Inhibitors
Peptide Model Systems for Amyloid Fiber Formation: Design Strategies and Validation Methods
Alexandra Esteras-Chopo, Maria Teresa Pastor, and Manuela Lopez de la Paz
Protein Misfolding Disorders and Rational Design of Antimisfolding Agents
Lisbell D. Estrada, June Yowtak, and Claudio Soto
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 316
Weight: 467g
Availability: Available
Subcategories: Biochemistry
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