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Main description:
Nuclear magnetic resonance imaging represents a technique that is indispensable in every day biomedical diagnostics. Thanks to the numerous ways to manipulate and detect an NMR signal, it is possible to obtain a variety of information with excellent spatial and temporal resolution. Today's MRI techniques go far beyond the illustration of pure anatomical structures and include the revealing of processes down to the molecular level. The number of small animal imaging centers relying on MRI as a key method for preclinical research to understand diseases and to test for novel treatments is growing rapidly. In Vivo NMR Imaging: Methods and Protocols is written as an experimental laboratory text to provide a descriptive approach of the various applications of magnetic resonance imaging and its underlying principles. Starting from a compact introduction of basic NMR physics and image encoding techniques suitable for a broad audience in the life sciences, the concept focuses on addressing the many ways of generating contrast in MR images. The authors cover an interdisciplinary range of problems to be addressed by this non-invasive modality, including study protocols for addressing morphological, physiological, functional, and biochemical aspects of various tissues in living organisms. Information about practical aspects of designing experimental studies that follow the special conditions for micro imaging setups are also provided.
Written in the successful Methods in Molecular Biology (TM) series format, In Vivo NMR Imaging: Methods and Protocols aims to be an experimental compendium of modern in vivo MR imaging with special focus on recent developments in molecular imaging and new protocols for imaging metabolism and molecular markers.
Contents:
Part I. Basics of MRI
1. Physical Basics of NMR
Rolf Pohmann
2. Spatial Encoding - Basic Imaging Sequences
Rolf Pohmann
3. Basic Contrast Mechanisms
Leif Schroeder and Cornelius Faber
4. Scanner Components
Volker Behr
5. Small Animal Preparation and Handling in MRI
Patrick McConville
Part II. Special Techniques
6. Cerebral Perfusion MRI in Mice
Frank Kober, Guillaume Duhamel, and Virginie Callot
7. High Field Diffusion Tensor Imaging in Small Animals and Excised Tissue
Bernadette Erokwu, Chris Flask, and Vikas Gulani
8. The BOLD Effect
Joan M. Greve
9. Screening of CEST MR Contrast Agents
Xiaolei Song, Kannie W.Y. Chan, and Michael T. McMahon
10. Hyperpolarized Noble Gases as Contrast Agents
Xin Zhou
11. Hyperpolarized Molecules in Solution
Jan Henrik Ardenkjaer-Larsen, Haukur Johannesson, Stefan J. Petersson, and Jan Wolber
12. MR Oximetry
Jeff F. Dunn
13. MRI using Intermolecular Multiple-Quantum Coherences
Rosa T. Branca
Part III. Brain Applications
14. Experimental Stroke Research: The Contributions of In vivo MRI
Therese Kallur and Mathias Hoehn
15. Volumetry and Other Quantitative Measurements to Assess the Rodent Brain
Alize Scheenstra, Jouke Dijkstra, and Louise van der Weerd
16. Models of Neurodegenerative Disease - Alzheimer's Anatomical and Amyloid Plaque Imaging
Alexandra Petiet, Benoit Delatour, and Marc Dhenain
17. MRI in Animal Models of Psychiatric Disorders
Dana S. Poole, Melly S. Oitzl, and Louise van der Weerd
18. Spectroscopic Imaging of the Mouse Brain
Dennis W. J. Klomp and W. Klaas Jan Renema
Part IV. Spine Applications
19. Spinal Cord - MR of Rodent Models
Virginie Callot, Guillaume Duhamel, and Frank Kober
Part V. Cardiovascular Applications
20. Assessment of Cardiac Function
Jurgen E. Schneider
21. Plaque Imaging in Murine Models of Cardiovascular Disease
Gert Klug, Volker Herold, and Karl-Heinz Hiller
22. Interventional MRI in the Cardiovascular System
Harald H. Quick
23. MR for the Investigation of Murine Vasculature
Christoph Jacoby and Ulrich Floegel
Part VI. Lung Applications
24. MRI of the Lung: Non-invasive Protocols and Applications to Small Animal Models of Lung Disease
Magdalena Zurek and Yannick Cremillieux
Part VII. Cancer Models
25. Characterization of Tumor Vasculature in Mouse Brain by USPIO Contrast-enhanced MRI
Giulio Gambarota and William Leenders
26. Cancer Models - A Multiparametric Application of MRI in Rodent Hepatic Tumor Model
Feng Chen, Frederik De Keyzer, and Yicheng Ni
Part VIII. Functional MRI
27. BOLD MRI Applied to a Murine Model of Peripheral Artery Disease
Joan M. Greve
28. Manganese-enhanced Magnetic Resonance Imaging
Susann Boretius and Jens Frahm
29. Spin Echo BOLD fMRI on Songbirds
Colline Poirier and Anne-Marie Van der Linden
Part IX. Phenotyping
30. MRI to Study Embryonic Development
Bianca Hogers
31. Mouse Phenotyping with MRI
X. Josette Chen and Brian J. Nieman
32. Analysis of Freshly Fixed and Museum Invertebrate Specimens using High-resolution, High-throughput MRI
Alexander Ziegler and Susanne Mueller
Part X. Metabolic and Targeted Imaging
33. Applications of Hyperpolarized Agents in Solutions
Jan Henrik Ardenkjaer-Larsen, Haukur Johannesson, J. Stefan Petersson, and Jan Wolber
34. Target-specific Paramagnetic and Superparamagnetic Micelles for Molecular MR Imaging
Roel Straathof, Gustav J. Strijkers, and Klaas Nicolay
35. Tracking Transplanted Cells by MRI - Methods and Protocols
Michel Modo
36. MRI of CEST Based Reporter Gene
Guanshu Liu and Assaf A. Gilad
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2011
Pages: 766
Weight: 1622g
Availability: Available
Subcategories: Radiology
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