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MORE ABOUT THIS BOOK
Main description:
Chemical genomics technology has been steadily improving, delivering new biological probes and drugs, and the explicit use of the term 'chemical proteomics' has increased with it, as proteins have always been at the heart of this technology. In Chemical Genomics and Proteomics: Reviews and Protocols, experts in the field present updated reviews of the chemistry of small molecules and their interaction with protein targets as well as detailed protocols that cover different types of ligands, carbohydrates, and lipids. For example, the generation of their protein targets and methods for measuring their interactions is covered. Written in the highly successful Methods in Molecular Biology (TM) series format, methodology chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Thorough and up to date, Chemical Genomics and Proteomics: Reviews and Protocols aims to provide inspiration to those who wish to use chemical genomics and proteomics in their work and develop this young field into full maturity through the incorporation of the new biological and chemical technologies beginning to emerge here.
Contents:
Part I: Reviews
1. Overview of Chemical Genomics and Proteomics
Edward D. Zanders
2. Exploring Chemical Space: Recent Advances in Chemistry
Yung-Sing Wong
3. In Silico Design of Small Molecules
Paul H. Bernardo and Joo Chuan Tong
4. Surface Plasmon Resonance for Proteomics
Nico J. de Mol
Part II: Protocols
5. Biomimetic Affinity Ligands for Immunoglobulins Based on the Multicomponent Ugi Reaction
Graziella El Khoury, Laura A. Rowe, and Christopher R. Lowe
6. Preparation of Photo-Cross-Linked Small Molecule Affinity Matrices for Affinity Selection of Protein Targets for Biologically Active Small Molecules
Hiroshi Takayama, Takashi Moriya, and Naoki Kanoh
7. Profiling Cellular Myristoylation and Palmitoylation Using -Alkynyl Fatty Acids
Rami N. Hannoush
8. Fluorescence Labels in Kinases (FLiK): A High-Throughput Kinase Binding Assay for the Identification of DFG-Out Binding Ligands
Jeffrey R. Simard and Daniel Rauh
9. Electrochemical Aptamer Sensor for Small Molecule Assays
Xin Liu, Wang Li, Xiahong Xu, Jiang Zhou, and Zhou Nie
10. Miniaturized, Microarray-Based Assays for Chemical Proteomic Studies of Protein Function
Jonathan M. Blackburn, Aubrey Shoko, and Natasha Beeton-Kempen
11. Glycan Microarrays
Xuezheng Song, Jamie Heimburg-Molinaro, David F. Smith, and Richard D. Cummings
12. Resolving Bottlenecks for Recombinant Protein Expression in E. coli
Yoav Peleg and Tamar Unger
13. Recombinant Protein Expression in the Baculovirus-Infected Insect Cell System
Tamar Unger and Yoav Peleg
14. Systems for the Cell-Free Synthesis of Proteins
Lei Kai, Christian Roos, Stefan Haberstock, Davide Proverbio, Yi Ma, Friederike Junge, Mikhail Karbyshev, Zhinan Xu, Volker Doetsch, and Frank Bernhard
15. Protein Identification by MALDI-TOF Mass Spectrometry
Judith Webster and David Oxley
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: October, 2011
Pages: 256
Weight: 716g
Availability: Available
Subcategories: Biochemistry, Genetics
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