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Main description:
This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.
Contents:
1. DQAsomes as the Prototype of Mitochondria-targeted Pharmaceutical Nanocarriers: Preparation, Characterization, and Use
Volkmar Weissig
2. Predicting Mitochondrial Targeting by Small Molecule Xenobiotics Within Living Cells Using QSAR Models
Richard W. Horobin
3. Targeting Mitochondria with Small Molecules: The Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide
Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, and Richard C. Hartley
4. Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes
Parul Benein, Mohammed Almuteri, Ahmed Mehanna, and Gerard G.M. D'Souza
5. Synthesis and Evaluation of 18F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging
Dong-Yeon Kim and Jung-Joon Min
6. Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria
Jose Teixeira, Pedro Soares, Sofia Benfeito, Michael P Murphy, Paulo J. Oliveira, and Fernanda Borges
7. Mitochondriotropic Nano-Emulsified Genistein-Loaded Vehicles for Cancer Therapy
Jimmy Pham, Oliver Grundmann, and Tamer Elbayoumi
8. Formulation and Optimization of Mitochondria-Targeted Polymeric Nanoparticles
Sean Marrache, Rakesh K. Pathak, and Shanta Dhar
9. Ex Vivo Generation of Functional Immune Cells by Mitochondria-Targeted Photosensitization of Cancer Cells
Sean Marrache, Smanla Tundup, Donald A. Harn, and Shanta Dhar
10. Targeting the Mitochondrial Genome Via a Dual Function MITO-Porter: Evaluation of mtDNA-Levels and Mitochondrial Function
Yuma Yamada and Hideyoshi Harashima
11. Mitochondrial, Acidic, and Cytosolic pHs Determination by 31P NMR Spectroscopy: Design of New Sensitive Targeted pH Probes
Marcel Culcasi, Sophie Thetiot-Laurent, Ariane Atteia, and Sylvia Pietri
12. Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related Research
Mikhail Y. Vyssokikh, Yury N. Antonenko, Konstantin G. Lyamzaev, Tatyana I. Rokitskaya, and Vladimir P. Skulachev
13. Synthesis and Testing of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin
Lucia Biasutto, Andrea Mattarei, and Cristina Paradisi
14. Evaluation of Respiration of Mitochondria in Cancer Cells Exposed to Mitochondria-Targeted Agents
Katarina Kluckova, Lan-Feng Dong, Martina Bajzikova, Jakub Rohlena, and Jiri Neuzil
15. The Effect of Mitochondrially Targeted Anti-Cancer Agents on Mitochondrial (Super)Complexes
Magdalena Vondrusova, Ayanachew Bezawork-Geleta, Karishma Sachaphibulkij, Jaroslav Truksa, and Jiri Neuzil
16. Mitochondrial Targeting of Recombinant RNA
Ilya Dovydenko, Anne-Marie Heckel, Yann Tonin, Ali Gowher, Alya Venyaminova, Ivan Tarassov, and Nina Entelis
17. Mitochondrial Targeting of Catalytic RNAs
Daria Mileshina, Adnan Khan Niazi, Eliza Wyszko, Maciej Szymanski, Romain Val, Clarisse Valentin, Jan Barciszewski, and Andre Dietrich
18. Allotopic Expression of ATP6 in the Mouse as a Transgenic Model of Mitochondrial Disease
David A. Dunn and Carl A. Pinkert
19. Analysis of Pollutant-Induced Changes in Mitochondrial DNA Methylation
Hyang-Min Byun and Timothy M. Barrow
20. ETS and DEAS Studies of the Reduction of Xenobiotics in Mitochondrial Intermembrane Space
Stanislav A. Pshenichnyuk and Alberto Modelli
21. Analysis of Mitochondrial Morphology and Function Under Conditions of Mitofusin 2 Deficiency
Juan Pablo Munoz and Antonio Zorzano
22. Yeast as a Tool to Study Mitochondrial Retrograde Pathway En Route to Cell Stress Response
Masa Zdralevic, Nicoletta Guaragnella and Sergio Giannattasio
23. Cell Energy Budget Platform for Assessment of Cell Metabolism
Dmitri B. Papkovsky and Alexander V. Zhdanov
24. Induced Pluripotent Stem Cells (iPSCs) for Modeling Mitochondrial DNA Disorders
Alessandro Prigione
25. Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice
Thomas Kolbe, Ralf Steinborn, and Joerg P. Burgstaller
26. In Vivo Visualization and Quantification of Mitochondrial Morphology in C. elegans
Reuben L. Smith, Winnok H. De Vos, Richard de Boer, Erik M.M. Manders, and Hans van der Spek
27. Mitochondrial DNA as a Biosensor of UV Exposure in Human Skin
Amy Bowman and Mark A. Birch-Machin
28. Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation
Matthias Hecker, Natascha Sommer, and Konstantin Mayer
29. Atomic Force Microscopy-Based Shape Analysis of Heart Mitochondria
Gi-Ja Lee and Hun-Kuk Park
30. Enzymatic Assays for Probing Mitochondrial Apoptosis
Zhenyu Wang, Claire Nicolas, Rodolphe Fischmeister, and Catherine Brenner
31. A Cybrid Cell Model for the Assessment of the Link Between Mitochondrial Deficits and Sporadic Parkinson's Disease
Daniela M. Arduino, A. Raquel Esteves, Russell H. Swerdlow, and Sandra M. Cardoso
32. Analysis of Mitochondrial Network by Imaging: Proof of Technique in Schizophrenia
Dorit Ben-Shachar, Edith Suss-Toby, and Odile Robicsek
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: January, 2015
Pages: 425
Weight: 652g
Availability: Available
Subcategories: General Issues, Pharmacology, Physiology
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