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Main description:
Arising from firm foundations laid by mathematical population genetics, clinical genetics, and statistical epidemiology, genetic epidemiology attempts to identify the many components of risk
attributable to genes, environments, and interactions, and the course of its research can follow many diverse paths. In Genetic Epidemiology, the success of genome-wide association studies in their identification of hundreds of disease susceptibility loci has inspired renowned experts to contribute thorough methodologies, which aim to bring together bioinformaticians, geneticists, clinicians, statisticians, and epidemiologists in the study of this vital field. The volume opens with chapters covering the basics; however, it quickly moves on to coverage of more specialist topics such as twin studies, Mendelian randomization, genetic association studies, more advanced areas, as well as case studies. As a part of the highly successful Methods in Molecular Biology (TM) series, this work provides the detailed description of the application and analysis of the most commonly employed methods that are necessary for a firm grounding in the field.
Authoritative and cutting-edge, Genetic Epidemiology aims to provide a basic framework for crucial interdisciplinary communication and understanding suited to newcomers to the field as well as experienced researchers and graduate level students.
Contents:
Part I: Introduction
1. Molecular Genetics and Genetic Variation
Mohammed Elfatih Twfieg and M. Dawn Teare
2. Terminology, Concepts, and Models in Genetic Epidemiology
M. Dawn Teare and Mauro F Santibanez Koref
3. An Introduction to Epidemiology
Cother Hajat
Part II: Genetic Linkage Mapping
4. Genetic Distance and Markers Used in Linkage Mapping
Kristina Allen-Brady and Nicola J. Camp
5. Approaches to Genetic Linkage Analysis
M. Dawn Teare
Part III: Genetic Mapping by Association
6. Fine-Scale Structure of the Genome and Markers Used in Association Mapping
Karen Curtin and Nicola J. Camp
7. Genome-Wide Association Studies
Mark M. Iles
8. Candidate Gene Association Studies
M. Dawn Teare
9. Family-Based Association Studies
Frank Dudbridge
10. Genome Variation: A Review of Web Resources
Andrew Collins and William Tapper
Part IV: Emerging Themes
11. Advanced Methods in Twin Studies
Jaakko Kaprio and Karri Silventoinen
12. Mendelian Randomization: A Tool for Assessing Causality in Observational Epidemiology
Nuala A. Sheehan, Sha Meng, and Vanessa Didelez
13. Copy Number Variation
Louise V. Wain and Martin D. Tobin
14. Epigenetic Variation
Kevin Walters
Part V: Case Studies
15. Modeling the Effect of Susceptibility Factors (HLA and PTPN22) in Rheumatoid Arthritis
Herve Perdry and Francoise Clerget-Darpoux
16. Coronary Artery Disease: An Example Case Study
Jennifer H. Barrett
17. The Genetic Epidemiology of Obesity: A Case Study
Laura Johnson
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2010
Pages: 256
Weight: 1460g
Availability: Available
Subcategories: Epidemiology, Genetics
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